Description

Understanding ARA-290’s Structure

Buy ARA-290 (16mg) in Texas. ARA-290 is an 11-amino acid synthetic peptide derived from erythropoietin’s helix B domain . Consequently, it mimics EPO’s tissue-protective effects without stimulating red blood cell production . Therefore, researchers value this non-hematopoietic peptide for studying tissue repair and inflammation pathways.

Key Research Applications and where to Buy ARA-290 (16mg) in Texas

Scientists study ARA-290 for its effects on neuropathic pain and nerve regeneration . Moreover, research demonstrates it reduces mechanical and cold allodynia in preclinical neuropathy models . Additionally, it suppresses spinal microglia activation and inflammatory responses . Notably, clinical studies showed reduced neuropathic symptoms in sarcoidosis patients with small fiber neuropathy .

Molecular Mechanism of Action

ARA-290 binds selectively to the innate repair receptor (IRR), a heterodimer of EPOR and CD131 . Subsequently, this activates JAK2/STAT and PI3K/Akt pro-survival pathways . Furthermore, it inhibits the NF-κB pathway, reducing pro-inflammatory cytokines like TNF-α and IL-1β . Therefore, researchers can Buy ARA-290 (16mg) in Texas from specialized suppliers for laboratory studies.

Neuroprotective and Tissue Protection Effects

ARA-290 demonstrates significant neuroprotection in cerebral ischemia models . Specifically, it reduced brain infarction volume and neuronal apoptosis in MCAO-induced stroke models . Also, it protects against cisplatin-induced nephrotoxicity through anti-apoptotic, anti-inflammatory, and antioxidant mechanisms . Thus, this peptide offers promising avenues for studying acute kidney injury and ischemic conditions.

Storage and Safety Compliance

Proper storage is vital for maintaining peptide stability and purity over time. Specifically, the lyophilized powder should be stored at -20°C away from light . Moreover, only trained professionals in laboratory environments should handle this compound . Consequently, you can Buy ARA-290 (16mg) in Texas from suppliers that clearly state their research-use policy and purity specifications.

FAQ About ARA-290

Q: What is ARA-290?
A: It is an 11-amino acid peptide derived from erythropoietin’s helix B domain.

Q: How does ARA-290 work?
A: It activates the innate repair receptor to suppress inflammation and promote cell survival.

Q: Is ARA-290 approved for human use?
A: No, it is strictly a research chemical for laboratory and scientific studies only .

Q: What purity is available for research?
A: Most suppliers offer ARA-290 with a purity of >98-99% as confirmed by HPLC analysis .

Q: How should ARA-290 be stored?
A: Store the lyophilized powder at -20°C; avoid repeated freeze-thaw cycles after reconstitution .